| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802785 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 8 Pages |
Abstract
⺠The effect of IRS1 silencing, by shRNA-lentiviral, in K562 cells was evaluated. ⺠IRS1 silencing decreased cell proliferation and colony formation. ⺠Inhibition of IRS1 arrested cells in the G0/G1 phase of cell cycle in K562 cells. ⺠IRS1 silencing resulted down modulation of Akt, P70S6K and ERK1/2 activity. ⺠IRS1 silencing downregulates Akt/mTOR and MAPK signaling in BCR-ABL cells.
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Authors
João Agostinho Machado-Neto, Patricia Favaro, Mariana Lazarini, Fernando Ferreira Costa, Sara T. Olalla Saad, Fabiola Traina,