| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802795 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 10 Pages |
Abstract
⺠Scutellaria baicalensis (SB) and SB-derived polyphenols possess anti-proliferative activities in pancreatic cancer. ⺠Baicalein decreased mRNA and protein expression of the anti-apoptotic Bcl-2 family protein Mcl-1 and induced apoptosis. ⺠Mcl-1 knock-down induced apoptosis through caspase cascade, but Bcl-2 or Bcl-xL knock-down had no or only a slight effect. ⺠The effect of baicalein on apoptosis was significantly attenuated by Mcl-1 over-expression.
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Authors
Hiroki Takahashi, Monica C. Chen, Hung Pham, Eliane Angst, Jonathan C. King, Jenny Park, Ethan Y. Brovman, Hideyuki Ishiguro, Diane M. Harris, Howard A. Reber, Oscar J. Hines, Anna S. Gukovskaya, Vay Liang W. Go, Guido Eibl,