| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802796 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 8 Pages |
Abstract
⺠Albumin and AGE, but not high glucose levels, increase heparanase expression in tubular cells. ⺠Heparanase up-regulation is mediated by PI3K/AKT pathway. ⺠Heparanase reduces heparan sulfate via its endoglycosidase activity. ⺠Heparanase reduces heparan sulfate throw the gene expression regulation of syndecan-1.
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Authors
Valentina Masola, Giovanni Gambaro, Elena Tibaldi, Maurizio Onisto, Cataldo Abaterusso, Antonio Lupo,