Article ID Journal Published Year Pages File Type
10802807 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2011 11 Pages PDF
Abstract
► Osteosarcoma patients develop pulmonary metastases, but its mechanisms remain unclear. ► MMP-1 and CXCR4 were notably expressed in a highly metastatic osteosarcoma cell line. ► MAPK pathways activated AP-1 (c-Jun/Fra-1), and thereby regulated MMP-1 expression. ► The MAPK/AP-1/MMP-1 axis plays a central role in osteosarcoma invasion.
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