Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10802807 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 11 Pages |
Abstract
⺠Osteosarcoma patients develop pulmonary metastases, but its mechanisms remain unclear. ⺠MMP-1 and CXCR4 were notably expressed in a highly metastatic osteosarcoma cell line. ⺠MAPK pathways activated AP-1 (c-Jun/Fra-1), and thereby regulated MMP-1 expression. ⺠The MAPK/AP-1/MMP-1 axis plays a central role in osteosarcoma invasion.
Keywords
SDF-1αRT-PCRERKETsECMFCSAP-1CXCR4c-Jun NH2-terminal kinaseMNNGMMP-1FRA-1Pea3WST-8IL-2RαE-twenty sixEMSAGAPDHNF-κBMMPPBSJnkMAPKN-methyl-N′-nitro-N-nitrosoguanidineSmall interfering RNAsiRNAElectrophoretic mobility shift assayOsteosarcomastandard deviationinterleukinEnzyme-linked immunosorbent assayELISAInvasionc-Junfetal calf serumStromal cell-derived factor-1αnuclear factor-κBExtracellular matrixmatrix metalloproteinasePulmonary metastasisPhosphate-buffered salinereverse transcription-PCRwild typeretinoblastoma proteinactivator protein-1mitogen-activated protein kinaseextracellular signal-regulated kinaseglyceraldehyde 3-phosphate dehydrogenase
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Authors
Ryuichiro Kimura, Chie Ishikawa, Takayoshi Rokkaku, Ralf Janknecht, Naoki Mori,