2,3,7,8-Tetrachlorodibenzo-p-dioxin impairs iron homeostasis by modulating iron-related proteins expression and increasing the labile iron pool in mammalian cells

Article ID	Journal	Published Year	Pages	File Type
10802816	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2011	9 Pages	PDF

Abstract

âºTCDD affects the maintenance of iron homeostasis. âºTCDD causes an opposite modulation of the iron regulatory proteins activity. âºTCDD determines an increase of TfR-1 expression and a decrease of ferritin content. âºTCDD causes an enlargement of the intracellular free iron pool. âºIRP2 becomes the effector of cellular iron homeostasis when TCDD exposure is prolonged.

Keywords

IRE IRPS DMT-1 2-ME MDBK salicylaldehyde isonicotinoyl hydrazone SIH TCDD LIP 2-mercaptoethanol 2,3,7,8-Tetrachlorodibenzo-p-dioxin 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide MTT Labile iron pool iron-responsive element Iron metabolism Divalent metal transporter 1 Iron regulatory proteins transferrin receptor 1

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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2,3,7,8-Tetrachlorodibenzo-p-dioxin impairs iron homeostasis by modulating iron-related proteins expression and increasing the labile iron pool in mammalian cells

Authors

Rita Santamaria, Filomena Fiorito, Carlo Irace, Luisa De Martino, Carmen Maffettone, Giovanna Elvira Granato, Antonio Di Pascale, Valentina Iovane, Ugo Pagnini, Alfredo Colonna,