Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10802825 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 9 Pages |
Abstract
⺠Visfatin-induced angiogenesis requires mTOR and GSK3β signaling downstream of the PI3-kinase/Akt signaling pathway. ⺠Activation of mTOR inactivates GSK3β, which promotes the nuclear translocation of β-catenin, thereby increasing the expression of cyclin D1 and VEGF. ⺠β-Catenin knockdown attenuates visfatin-induced endothelial cell proliferation and capillary tube formation. ⺠Collectively, these results show that the activation of mTOR and the inactivation of GSK3β play key roles in visfatin-induced angiogenesis.
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Authors
Joo-Won Park, Won-Ho Kim, So-Hee Shin, Ji Yeon Kim, Mi Ran Yun, Keon Jae Park, Hyun-Young Park,