Article ID Journal Published Year Pages File Type
10802829 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2011 8 Pages PDF
Abstract
► Adiponectin receptors are expressed in human adrenocortical (H295R) cells. ► Adiponectin increases StAR protein expression and cortisol secretion. ► Adiponectin induces increase in expression of key steroidogenic genes. ► Adiponectin induces activation of ERK1/2 and AMPK kinase in H295R cells. ► AMPK and ERK inhibitions result in reduction of adiponectin-mediated StAR expression.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Adiponectin (15-36) stimulates steroidogenic acute regulatory (StAR) protein expression and cortisol production in human adrenocortical cells: Role of AMPK and MAPK kinase pathways
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