| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802841 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 11 Pages |
Abstract
⺠The cytokine interleukin-6 (IL-6) has pro- and anti-inflammatory properties. ⺠Whereas only few cells express the IL-6 receptor and respond to IL-6 (classic signaling), all cells can be stimulated via a soluble IL-6 receptor (trans-signaling) since gp130 is ubiquitously expressed. ⺠Classic- and trans-signaling can be differentially inhibited. ⺠Apparently, IL-6 via classic signaling has regenerative and anti-inflammatory functions whereas trans-signaling is pro-inflammatory.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Jürgen Scheller, Athena Chalaris, Dirk Schmidt-Arras, Stefan Rose-John,