| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802844 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 12 Pages |
Abstract
⺠Intracellular signals and interactions with AKAP regulate CRH-R2β-ERK activation. ⺠CRH-R2β induces PKB/Akt activation via Gi/o-proteins-PI3-K activation. ⺠ERK phosphorylates β-arr1 and modulates its translocation to the plasma membrane. ⺠Inhibition of either PKA or ERK pathway accelerates CRH-R2β endocytosis. ⺠The Akt signaling is insensitive to changes in receptor endocytosis rate.
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Authors
Danijela Markovic, Anu Punn, Hendrik Lehnert, Dimitris K. Grammatopoulos,