| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802849 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 9 Pages |
Abstract
⺠“EF-hand” proteins convey intracellular Ca2+ signals in the presence of ~1000-fold excess of Mg2+. ⺠Due to stereochemical constraints Mg2+ ion cannot engage the ligands of an EF-hand in the same way as Ca2+. ⺠Mg2+ plays an active role in the Ca2+-dependent regulation of cellular processes by stabilizing the “off state” of some EF-hand proteins. ⺠Some pathological conditions attributed to Mg2+ deficiency might be related to excessive activation of underlying Ca2+-regulated cellular processes.
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Authors
Zenon Grabarek,