| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802852 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 13 Pages |
Abstract
âºCholesterol modulates the membrane binding and intracellular distribution of AnxA6. âºAnxA6-induced alterations in cholesterol transport and caveolin export from the Golgi. âºAnxA6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity. âºAnxA6 inhibits Ras signaling in breast cancer cells. âºAnxA6 overexpression stabilizes cortical actin.
Keywords
cPLA2SNAP (Soluble NSF Attachment Protein) receptorAnnexin A6NRKcytoplasmic phospholipase A2RAS/MAPKNPC1TGNPKCαDRMSOCEPKCSNAREEGFReNOSBCCPI3KHDLERKMAPKPI(4,5)P2Arachidonic acidactinChoChinese Hamster OvaryCaveolaeBreast cancer cellsDetergent resistant membranesPhosphatidylserinephosphoinositide 3-kinasehigh density lipoproteinlow density lipoproteinLDLStore-operated Ca2+ entryProtein kinase Cmitogen-activated protein kinasecaveolin-1Cav-1cholesterolnormal rat kidneyextracellular signal-regulated kinaseEpidermal growth factor receptor
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Authors
Carlos Enrich, Carles Rentero, Sandra Vilà de Muga, Meritxell Reverter, Vishwaroop Mulay, Peta Wood, Meryem Koese, Thomas Grewal,