| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802865 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 13 Pages |
Abstract
⺠CaMy1 directly interacts with human brain SCG10 in Ca2+-dependent manner in vivo. ⺠CaMy1/SCG10 binding involves CaMy1 C-terminal domain and N-terminal SCG10 fragment. ⺠CaMy1 and SCG10 protein levels increase during early neural development. ⺠CaMy1 co-localizes with SCG10 in developing neurons. ⺠CaMy1 modulates SCG10-related neurite outgrowth and microtubule dynamics.
Keywords
PFACalmyrinNbr1CIB13-ATNi-NTASCG10PAX3NGFNCSGSTIPTGFBSPLAGFPPBSMBPDMEMisopropyl-1-thio-β-d-galactopyranoside3-amino-1,2,4-triazoleDulbecco's modified Eagle MediumProximity ligation assaysodium dodecyl sulfate-polyacrylamide gel electrophoresisSDS-PAGEanalysis of varianceANOVAneuronal developmentBinding domainactivation domainDIVdays in vitroMicrotubulefetal bovine serumCalcium signalingnerve growth factorPhosphate-buffered salinepolymerase chain reactionPCRparaformaldehydegreen fluorescent proteinmaltose-binding proteinglutathione S-transferase
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Authors
Adam Sobczak, Katarzyna Debowska, Magdalena Blazejczyk, Michael R. Kreutz, Jacek Kuznicki, Urszula Wojda,