Cell surface targeting of myelin oligodendrocyte glycoprotein (MOG) in the absence of endoplasmic reticulum molecular chaperones

► Myelin oligodendrocyte glycoprotein (MOG) has important implication in multiple sclerosis, our data show that calnexin, an endoplasmic reticulum chaperone, forms complexes with MOG, suggesting that calnexin is a potential chaperone for this protein. ► Importantly we discover that cell surface trafficking of MOG in not disrupted in the absence of essential endoplasmic reticulum chaperones. ► Our results provide new insights into folding and processing of MOG-an important antigen involved in multiple sclerosis.