| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802888 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 12 Pages |
Abstract
⺠EGF-like protein DLK2 interacts with DLK1/Pref-1 and the EGF 10-15 region of NOTCH1 receptor. ⺠DLK2 protein inhibits NOTCH activity. ⺠DLK proteins compete with JAGGED1 and DLL4 canonical ligands for NOTCH receptor binding. ⺠The co-expresion of DLK1 and DLK2 results in higher levels of NOTCH activity.
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Authors
Beatriz Sánchez-Solana, MarÃa Luisa Nueda, MarÃa Desamparados Ruvira, MarÃa José Ruiz-Hidalgo, Eva MarÃa Monsalve, Samuel Rivero, José Javier GarcÃa-RamÃrez, MarÃa José M. DÃaz-Guerra, Victoriano Baladrón, Jorge Laborda,