Article ID Journal Published Year Pages File Type
10802898 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2011 9 Pages PDF
Abstract
► Chk1 protein levels are regulated differently depending on glucose concentrations. ► Chk1 is degraded through the ubiquitin-proteasome pathway upon glucose deprivation. ► The molecular mechanism is distinct from genotoxic stress-induced degradation. ► Glucose deprivation induces defective checkpoint response to replication blocks.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteasome pathway and effective checkpoint response to replication blocks
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