| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10802902 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 | 7 Pages |
Abstract
⺠TFPI2 expression is upregulated in human macrophages by thrombin exposure. ⺠Thrombin induced TFPI2 expression involves cAMP, ERK1/2 and JNK pathways, leading finally to NFkB activation. ⺠TFPI2 induction by thrombin is independent of EGFR and COX-2, and does not involve AP-1 activation. ⺠In the context of atherosclerosis TFPI2 induction could represent a regulatory mechanism to avoid excessive MMP activation.
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Authors
Jordi Pou, Alba Rebollo, LÃdia Piera, Manuel Merlos, Núria Roglans, Juan C. Laguna, Marta Alegret,