| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10803686 | Biochimie | 2013 | 8 Pages |
Abstract
⺠Mouse GX sPLA2 activity on phospholipid monolayers was measured for the first time. ⺠The substrate specificity of mGX was dependent on surface pressure. ⺠mGX acts on PE and PG but not on PC at surface pressure of biological membranes. ⺠Conditions can be found where the propeptide does not repress PLA2 activity. ⺠Structural modeling of mGX shows how the propeptide impairs access to the active site.
Keywords
PoPCDLPCPOPGInterfacial enzymologyPLPCi-face1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine1,2-dilauroyl-sn-glycero-3-phosphocholineamino acidphosphatidylcholinephosphatidylethanolaminePhospholipidsMonomolecular filmsPOPE
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Authors
Vanessa Point, Anaïs Bénarouche, Ikram Jemel, Goetz Parsiegla, Gérard Lambeau, Frédéric Carrière, Jean-François Cavalier,