| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10803689 | Biochimie | 2013 | 5 Pages |
Abstract
Lipid peroxidation generates a variety of lipid aldehydes, which have been recognized to modify protein and DNA, causing inflammation and cancer. However, recent studies demonstrate that phosphatidylethanolamine (PE) is a major target for these aldehydes, forming aldehyde-modified PEs (al-PEs) as a novel family of mediators for inflammation. This review summarizes our current understanding of these al-PEs, including formation, detection, structural characterization, physiological relevance and mechanism of action.
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Authors
Lilu Guo, Sean S. Davies,