Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10803717 | Biochimie | 2013 | 8 Pages |
Abstract
⺠Translationally controlled tumor protein (TCTP), also known as HRF, shows cytokine-like activity. ⺠TCTP exhibits cytokine-like functions only after it is modified by proteases, oxidants, or IgE in the inflamed sites. ⺠This review shows that dimerization is the critical modification of TCTP responsible for its cytokine-like activity. ⺠It further discusses the clinical relevance of dimerized TCTP to allergic diseases, and in the therapy of these diseases.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Miyoung Kim, Jeehye Maeng, Kyunglim Lee,