Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10803722 | Biochimie | 2013 | 10 Pages |
Abstract
⺠A novel metalloproteinase (AHPM) was purified from Agkistrodon halys pallas venom. ⺠AHPM is a non-hemorrhagic P-IIIc SVMP with α-fibrinogenolytic activity. ⺠AHPM hydrolyzes casein and fibrinogen and also dissolves fibrin clots. ⺠AHPM inhibits collagen-and ADP-induced platelet aggregation. ⺠The bifunctional enzyme has a potential clinical application as a thrombolytic agent.
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Authors
Jiajia Song, Xiaolong Xu, Yan Zhang, Mingchun Guo, Xincheng Yan, Shasha Wang, Shang Gao,