Article ID Journal Published Year Pages File Type
10803754 Biochimie 2013 12 Pages PDF
Abstract
► Angiotensin II (Ang II) increases MMP-3 and -13 productions via AT1 in osteoblasts. ► Phosphorylation of ERK1/2, p38 MAPK, and SAPK/JNK is increased by Ang II treatment. ► MEK1/2 and JNK inhibitor suppressed Ang II-induced MMP-3 and -13 productions. ► Ang II does not influence the plasminogen/plasmin pathway in osteoblasts. ► Ang II may stimulate the degradation process that occurs during turnover in osteoid.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Angiotensin II induces the production of MMP-3 and MMP-13 through the MAPK signaling pathways via the AT1 receptor in osteoblasts
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