Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10803767 | Biochimie | 2012 | 9 Pages |
Abstract
⺠3â²-amino-2â²,4â²-BNA modified TFO significantly stabilized triplex at physiological pH. ⺠3â²-amino-2â²,4â²-BNA modified TFO promoted triplex formation at physiological pH. ⺠3â²-amino-2â²,4â²-BNA modification increased nuclease resistance of TFO in human serum. ⺠Number and position of TFO modification did not affect degree of triplex promotion. ⺠Design of TFO with increased rigidity and hydration promoted triplex formation.
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Authors
Hidetaka Torigoe, Osamu Nakagawa, Takeshi Imanishi, Satoshi Obika, Kiyomi Sasaki,