| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10803810 | Biochimie | 2005 | 9 Pages |
Abstract
⺠LPA induces p42/44 MAPK activation in MG-63 cells via LPA1-LPA3 receptor. ⺠Gαi-dependent activation through the Src family of tyrosine kinases induces functional Egr-1 expression. ⺠LPA-induced Egr-1 upregulation was accompanied by a time-dependent decrease of periostin. ⺠Silencing of LPA1 and/or Egr-1 in MG-63 cells reversed LPA-mediated suppression of periostin.
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Authors
Werner Windischhofer, Evelyn Huber, Christine Rossmann, Michaela Semlitsch, Kerstin Kitz, Anamaria Rauh, Trevor Devaney, Hans-Jörg Leis, Ernst Malle,