Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10803819 | Biochimie | 2013 | 5 Pages |
Abstract
MicroRNAs (miRNAs) are a class of approximately 20-nucleotides single-stranded endogenous RNAs that regulate gene expression at the post-transcriptional level. miRNAs have recently been known to regulate cell proliferation, differentiation, and apoptosis. Fibrosis is the leading cause of organ dysfunction in diseases and results from an imbalance in the turnover of extracellular matrix components. Accumulating studies have demonstrated that miR-29 family participates in the development of liver fibrosis, renal fibrosis, pulmonary fibrosis, cardiac fibrosis. In this review, we are discussing the comprehensive role of miR-29 family in moderating profibrotic effect and its potential as therapeutic approach to fibrosis diseases.
Keywords
miR-29 familyFXRSmad3PDGFCTGFHGFFBN1MmpsIGFLPSTGF-βHSCα-SMANF-κBECM3′untranslated region3′UTRα-smooth muscle actintransforming growth factor-βHepatic stellate cellHepatocyte growth factorConnective tissue growth factorplatelet-derived growth factorInsulin-like growth factornuclear factor kappa BlipopolysaccharideExtracellular matrixMatrix metalloproteinasesReviewMicroRNAMiRNAcolcollagens
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Authors
Yong He, Cheng Huang, Xiang Lin, Jun Li,