Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension

► Long-sarafotoxins from snake venoms form a new family of endothelin-like compounds. ► They display different C-terminus extensions that follow the invariant Trp21. ► They have conserved core 3-D structures with variable C-terminus conformations. ► Extensions determine their affinity and selectivity towards endothelin-receptors. ► C-terminus extensions are crucial in their various pharmacological profiles.