| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10803866 | Biochimie | 2012 | 9 Pages |
Abstract
⺠Here we studied the metal induced regulation of the activity in the ADP-dependent kinase family. ⺠We used as model two glucokinases and a phosphofructokinase from hyperthermophilic archaea. ⺠Kinetic experiments showed that only glucokinases are strongly inhibited by free metal. ⺠Molecular modeling suggests that the presence of divalent metals is key for activity and regulation. ⺠The metal induced inhibition is the first regulatory mechanism proposed for this protein family.
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Authors
Felipe Merino, Jaime Andrés Rivas-Pardo, Andrés Caniuguir, Ivonne GarcÃa, Victoria Guixé,