| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10803884 | Biochimie | 2013 | 13 Pages |
Abstract
⺠We purified one of the major hemorrhagic factors, VaH3, from Vipera ammodytes ammodytes venom. ⺠We cloned and sequenced the full-length cDNA of VaH3. ⺠VaH3 is the first V. a. ammodytes SVMP to be fully sequenced. ⺠VaH3 degrades basal membrane, extracellular matrix and plasma proteins. ⺠A three-dimensional model of VaH3 provided an instrument to study mammalian ADAM/ADAMTS.
Keywords
ECMGPIbADAMTSMeropsPrPDSFSVMPvWFPPPRMSDVipera ammodytes ammodytesADAMroot-mean-square deviationa disintegrin and metalloproteinasedisSnake venomStructureEndothelial celldisintegrin-likeVon Willebrand factorBasal membraneCysteine-richFactor XDifferential scanning fluorimetryExtracellular matrixMetalloproteinaseSnake venom metalloproteinaseHemorrhaginplatelet-poor plasmaplatelet-rich plasma
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Authors
Tamara Sajevic, Adrijana Leonardi, Lidija KovaÄiÄ, Maja Lang-Balija, Tihana KurtoviÄ, Jože PungerÄar, Beata Halassy, Alenka TrampuÅ¡-Bakija, Igor Križaj,