| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10803885 | Biochimie | 2013 | 6 Pages |
Abstract
⺠We developed a system of four skin cell lines with increasing tumorigenic potentials. ⺠Glycolysis (BEC and Gal/Glu indexes measured) increased gradually with tumorigenicity. ⺠OXPHOS expression and activity and mitochondrial ATP synthesis were unchanged. ⺠Higher ROS levels (threefold) were found as an early event during tumor progression. ⺠The cell model presented is a suitable tool to investigate metabolic reprogramming.
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Authors
Carmen G. Vallejo, Alberto Cruz-Bermúdez, Paula Clemente, Rosana Hernández-Sierra, Rafael Garesse, Miguel Quintanilla,