| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10803894 | Biochimie | 2013 | 7 Pages |
Abstract
⺠Methionine deprivation induces both the amino acid response and the antioxidant response. ⺠HSF1 is inactivated upon methionine deprivation. ⺠Methionine starvation results in an HSF1-independent increase in HSPA1A and DNAJB1 mRNA levels. ⺠Activation of NRF2 results in increased HSPA1A mRNA levels.
Keywords
DNAJB1GCN2HSF1HMOX1Kelch-like ECH associated protein 1AsnSGSTPHSEATFGlutathione S-transferase PSAMNACTPA-responsive elementNrf2tPAkeap1EpREN-acetylcysteineasparagine synthetaseS-adenosylmethionineTREheat shock factor 1heat shock elementantioxidant response elementelectrophile-responsive elementactivating transcription factorMethionineAmino acid deprivationAREheme oxygenase 1
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Authors
Sanne M.M. Hensen, Lonneke Heldens, Chrissy M.W. van Enckevort, Siebe T. van Genesen, Ger J.M. Pruijn, Nicolette H. Lubsen,