Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10803902 | Biochimie | 2013 | 7 Pages |
Abstract
⺠The activity of each domain of ANT(3â³)/AAC(6â²) is independent of the other domain. ⺠ANT(3â³) plays a critical role in binding of aminoglycosides to AAC(6â²). ⺠Many (d)NTPs are accepted equally well as cosubstrates of ANT(3â³)/AAC(6â²). ⺠CoA analogs are preferentially transferred to 4,6-disubstituted aminoglycosides.
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Authors
Keith D. Green, Sylvie Garneau-Tsodikova,