| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10803910 | Biochimie | 2013 | 14 Pages |
Abstract
⺠Thymidine glycol is a biologically active oxidative lesion in DNA and affects biochemical processing of DNA. ⺠Due to chirality of C5 and C6 atoms, thymidine glycol exists as a mixture of two pairs of cis- and trans-diastereomers. ⺠Thymidine glycol represents a strong block to high-fidelity DNA polymerases in vitro and is lethal in vivo. ⺠Thymidine glycol is often found in tandem (clustered) lesions.
Keywords
TCr2-deoxyribonolactone5-hydroxyuracil5-OHU2′-deoxynucleoside 5′-triphosphate8-oxoGdNTPBERTLS5-hydroxycytosine8-oxo-7,8-dihydro-2′-deoxyguanosineapurinic/apyrimidinicNEROxidative DNA damageTranscription-coupled repairnucleotide excision repairbase excision repairThymidine glycolThymine glycoltranslesion DNA synthesistranslesion synthesis
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Biochemistry
Authors
Nina G. Dolinnaya, Elena A. Kubareva, Elena A. Romanova, Roman M. Trikin, Tatiana S. Oretskaya,