| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10803923 | Biochimie | 2013 | 7 Pages |
Abstract
⺠A new conjugate of the oxyntomodulin and polysialic acid was synthesized. ⺠Pure conjugate was obtained by the two-stage chromatography purification. ⺠Polysialic acid was attached to the oxyntomodulin at the N-terminus. ⺠Conjugate was assayed as an appetite inhibitor on lean fasted mice model. ⺠An anorexic effect, lasting for 8 h, was detected at a 15 μmol/kg dose.
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Authors
Ivan Vorobiev, Viktor Matskevich, Sergey Kovnir, Nadezhda Orlova, Vera Knorre, Sanjay Jain, Dmitry Genkin, Alexandre Gabibov, Anatoly Miroshnikov,