| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10803936 | Biochimie | 2013 | 8 Pages |
Abstract
⺠Harmine was identified to be an inducer of CCN2 that promotes cartilage generation. ⺠Harmine increased the expression of aggrecan, collagen type II and SOX-9 genes. ⺠Harmine induced chondrogenesis of ATDC5 cells in micromass cultures. ⺠Harmine rescued TNFα-induced decrease in expression of CCN2 and cartilage markers.
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Authors
Emilio Satoshi Hara, Mitsuaki Ono, Satoshi Kubota, Wataru Sonoyama, Yasutaka Oida, Takako Hattori, Takashi Nishida, Takayuki Furumatsu, Toshifumi Ozaki, Masaharu Takigawa, Takuo Kuboki,