| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10803962 | Biochimie | 2012 | 9 Pages |
Abstract
⺠Canine-human chimeric uricases were constructed to study the loss of hominoid uricase. ⺠The side-chains of Arg119 are crucial in maintaining the stability of active uricase. ⺠Inactivating mutation at codon 119 is proposed to occur first in human and great apes. ⺠The loss of hominoid uricase was caused by progressive multistep mutations. ⺠Reduction in uricase activity has been an evolutionary tendency in all mammals.
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Authors
Chun Zhang, Kai Fan, Weitao Zhang, Ruixin Zhu, Lujia Zhang, Dongzhi Wei,