| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10803982 | Biochimie | 2013 | 10 Pages |
Abstract
⺠In A7r5 cells, oxysterols ablate Ca2+ responses to hormones. ⺠This is due to effects on release of Ca2+ from internal stores. ⺠Oxysterols downregulate IP3R1 and ryanodine receptor proteins. ⺠IP3R1 downregulation by 7β-hydroxycholesterol is concentration and time dependent. âºÂ IP3R1 downregulation involves proteosomal proteolysis.
Keywords
7-ketooxLDL25-OHPMCA7β-OHGPCRRyRAVPVGCCThapsigarginIP3R7-Ketocholesterol7β-hydroxycholesterolDMSOG-protein coupled receptorOxidized LDLAtherosclerosisOxysterolbradykininDimethyl sulfoxidePlatelet activating factorsmooth muscle SERCALDLlow-density lipoproteinsPAFvoltage-gated calcium channelCalciumInositol 1,4,5-trisphosphate receptorRyanodine receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Yzzam Hammoud, Tom Rice, John J. Mackrill,