24S-hydroxycholesterol in plasma: A marker of cholesterol turnover in neurodegenerative diseases

Article ID	Journal	Published Year	Pages	File Type
10803985	Biochimie	2013	18 Pages	PDF

Abstract

âº Cholesterol is transformed in 24S-hydroxycholesterol (24OHC) by brain neurons. âº Almost all the plasma 24OHC in humans has brain origin. âº Plasma 24OHC depends by brain cholesterol turnover and liver elimination. âº Plasma 24OHC is reduced in neurodegenerative diseases proportionally to disease burden. âº Inconsistent results were found about plasma 24OHC in neurodegenerative diseases.

Keywords

NFT Hmg APP COA PPMS relapsing remitting MS SREBP LXR CYP51 SRE sterol responsive element binding protein PLP NSS ABC BACE WMH OCD htt RRMs HMGCR total tau protein Primary Progressive MS YAC PGC1a CETP Neural stem t-tau Statistically significant MBP CYP46A1 ACAT β-secretase 1 Aβ SCAP CYP27A1 24S-hydroxycholesterol 27-Hydroxycholesterol acyl-CoA:cholesterol acyltransferase HMG-CoA reductase P-Tau Apoe white matter hyperintensities mild cognitive impairment sterol 27-hydroxylase MRI Oxysterols amyloid beta Alzheimer disease Huntington disease Parkinson's disease Insig Biomarker Magnetic resonance imaging Dementia ATP-binding cassette transporter CNS Vascular dementia central nervous system endoplasmic reticulum Mass spectrometry low density lipoproteins LDL CSF Cerebrospinal fluid Multiple sclerosis Huntingtin MCI cholesteryl ester transfer protein srebp cleavage-activating protein C reactive protein CRP Myelin basic protein amyloid precursor protein Insulin Induced Gene liver X receptor Yeast artificial chromosome Cholesterol 24-hydroxylase cholesteryl ester coenzyme A