| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804000 | Biochimie | 2012 | 6 Pages |
Abstract
⺠Chemical manipulations made on broad HMT inhibitors afforded compounds more selectively. ⺠Bis(dibromo) analogs 5 and 10 showed selective activity against PR-SET7. ⺠Bis(monobromo) analogs 4 and 9 showed dual PR-SET7 and EZH2 inhibition. ⺠Bis(monobromo) analog 4 induced massive cell death in U937 cells.
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Authors
Sergio Valente, Ilaria Lepore, Carmela Dell'Aversana, Maria Tardugno, Sabrina Castellano, Gianluca Sbardella, Stefano Tomassi, Salvatore Di Maro, Ettore Novellino, Roberto Di Santo, Roberta Costi, Lucia Altucci, Antonello Mai,