| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804002 | Biochimie | 2012 | 7 Pages |
Abstract
⺠We show DNA methylation dynamics in the CYP3A4 regulatory region in human livers. ⺠CpGs near CYP3A4 transcription factor (TF) binding regions show variable methylation. ⺠Single CpG methylation near proximal promoter and CLEM4 may predict CYP3A4 expression. ⺠Hypomethylation near TF binding regions may explain fetal/adult CYP3A4 shift. ⺠DNA promoter methylation dynamics may be used to explain variable CYP3A4 expression.
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Authors
Marina Kacevska, Maxim Ivanov, Annika Wyss, Silva Kasela, Lili Milani, Anders Rane, Magnus Ingelman-Sundberg,