| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804005 | Biochimie | 2012 | 6 Pages |
Abstract
⺠The increase in BMP-2 induced bone formation in the presence of PDE4 inhibitor was studied. ⺠ALP, Runx2, Osx, and OCN were analyzed in the osteoblast differentiation. ⺠BMP-2 induced bone formation acts via Smad pathways. ⺠Osteogenesis enhancement due to BMP-2 and PDE4 inhibitor is correlated with the activation of 2 pathways: Smad and cAMP. MSCs treated with BMP-2 and cilomilast showed more rapid mineralisation.
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Authors
Maria Chiara Munisso, Jeong-Hun Kang, Makoto Tsurufuji, Tetsuji Yamaoka,