Article ID Journal Published Year Pages File Type
10804008 Biochimie 2012 9 Pages PDF
Abstract
► Novel fluorometric assay for analysis of retroviral integrase activity is developed. ► DNA binding and 3′-processing activities can be studied in real time. ► The method can be used for high-throughput screening of 3′-processing inhibitors. ► New inhibitors of HIV-1 integrase are found using this assay.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
A new fluorometric assay for the study of DNA-binding and 3′-processing activities of retroviral integrases and its use for screening of HIV-1 integrase inhibitors
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