Article ID Journal Published Year Pages File Type
10804015 Biochimie 2012 7 Pages PDF
Abstract
► Beside protein, free amino acid N-carbamoylation may play a pathological role in uremia. ► Threonine chloramine formation can limit the cell/protein destroying effect of HOCl. ► The limiting effect was completely lost by N-carbamoylation of threonine. ► HOCl generated volatile oxidant species from N-carbamoyl-threonine but not threonine. ► Cytotoxic protein modifying NH2Cl was identified as a component on these species.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Carbamoylated free amino acids in uremia: HOCl generates volatile protein modifying and cytotoxic oxidant species from N-carbamoyl-threonine but not threonine
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