(+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans

Article ID	Journal	Published Year	Pages	File Type
10804060	Biochimie	2012	10 Pages	PDF

Abstract

âº (+)-Medioresinol triggered accumulation intracelluar ROS in Candida albicnas cells. âº (+)-Medioresinol may induced mitochondrial membrane depolarzation and then Cyt c release from mitochondria to cytosol. âº (+)-Medioresinol activates metacaspases. âº (+)-Medioresinol induced apoptosis mediated mitochondria.

Keywords

DAPI Cyt C JC-1 DHR-123 4′, 6-diamidino-2-phenylindole ROS Hydrogen peroxide Terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL Apoptosis dihydrorhodamine-123 cytochrome c H2O2 Propidium iodide Candida albicans Reactive oxygen species