| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804063 | Biochimie | 2012 | 9 Pages |
Abstract
⺠RGD disintegrins block avb3 integrin-mediated signaling. ⺠These proteins inhibit angiogenesis and are under current clinical trials. ⺠DisBa-01 downregulates VEGF and VEGFR expression in endothelial cells. ⺠This RGD disintegrin inhibits MMP-2 activity. ⺠DisBa-01 increases MMP-9 activity which increases its anti-angiogenic effect.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Cyntia F. Montenegro, Carmen L. Salla-Pontes, Juliana U. Ribeiro, Aline Z. Machado, Rafael F. Ramos, Camila C. Figueiredo, Verônica Morandi, Heloisa S. Selistre-de-Araujo,