| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804073 | Biochimie | 2012 | 10 Pages |
Abstract
⺠The paradox of ATP utilization, for AZT removal, by HIV-1 resistant RT. ⺠AZT-resistance mutations are not advantageous for in vitro reverse transcription. ⺠Flagged-pyrophosphatase is associated with HIV-1 viral-like particles. ⺠Viral particles devoided of cellular microvesicles exhibit pyrophosphatase activity. ⺠Low pyrophosphate during reverse transcription explains ATP-driven resistance.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Céline Ducloux, Marylène Mougel, Valérie Goldschmidt, Ludovic Didierlaurent, Roland Marquet, Catherine Isel,