Article ID Journal Published Year Pages File Type
10804079 Biochimie 2012 10 Pages PDF
Abstract
► Halogenated derivatives of 360A G-quadruplex ligand have been synthesized. ► Halogenated 360A derivatives display potent affinity and selectivity for telomeric G-quadruplex over duplex DNA. ► 360A-Br induces delayed growth inhibition in HT1080 tumor cell line. ► 360A-Br triggers mild modifications of the telomeric C-strand resection using C-STELA assay.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Effects of a halogenated G-quadruplex ligand from the pyridine dicarboxamide series on the terminal sequence of XpYp telomere in HT1080 cells
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