| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804082 | Biochimie | 2012 | 8 Pages |
Abstract
⺠Novel chymotrypsin-like activity implicated in the maintenance of cell viability. ⺠Inhibition by TMR-PheP(OPh)2 caused a decrease in HeLa and U251 cell viability. ⺠Reduced viability was associated with an increase in caspase-3 activity over time. ⺠PARP cleavage and phosphatidylserine translocation were also observed. ⺠Inhibition of this protease initiates a cascade of apoptotic-related events.
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Authors
K.L. Moffitt, B. Walker, S.L. Martin,