Article ID Journal Published Year Pages File Type
10804091 Biochimie 2012 8 Pages PDF
Abstract
► DNA intercalators bind to supercoiled, nicked, and relaxed DNA templates with different DNA-binding enthalpies. ► DNA supercoiling enthalpy of plasmid pXXZ6, a 4.5 kb plasmid was determined to be ∼11.5 kcal/mol per ΔLk. ► The unfavorable ΔGS stemmed exclusively from a large (+) ΔHS and was compensated by a large, favorable TΔSS.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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