| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804102 | Biochimie | 2012 | 8 Pages |
Abstract
⺠rPnTx1 order of potency: rNaV1.2 > rNaV1.7 â rNaV1.4 â¥Â rNaV1.3 > mNaV1.6 â¥Â hNaV1.8. ⺠The IC50 for NaV1.2 was 33.7 ± 2.9 nM. ⺠rPnTx1 was inactive on several arthropod NaV channel isoforms. ⺠Of great interest is rPnTx1 high selectivity toward Nav1.7 channels. ⺠rPnTx1 becomes a promising tool for the development of analgesics.
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Authors
Anita O. Silva, Steve Peigneur, Marcelo R.V. Diniz, Jan Tytgat, Paulo S.L. Beirão,