Article ID Journal Published Year Pages File Type
10804127 Biochimie 2012 9 Pages PDF
Abstract
► The specific inhibition of hormone-sensitive lipase (HSL) by oxadiazolones was studied. ► The IC50 of compound 7600 and compound 9368 was found to be around 250 nM and 90 nM, respectively. ► The HSL inhibition is reversed in the presence of lipid substrate. ► The mechanism of the reversible inhibition of HSL by compound 7600 was investigated using LC-MS.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
The molecular mechanism of human hormone-sensitive lipase inhibition by substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones
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