| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10804164 | Biochimie | 2012 | 11 Pages |
Abstract
⺠We identify the HSP90 protein as a novel interaction partner for GABARAPL1. ⺠Amino-acids 1 to 22 of GABARAPL1 are important for the interaction with HSP90. ⺠GABARAPL1 and HSP90 partially colocalize in rat brain and in MCF-7 cells. ⺠17-AAG promotes proteasome-dependent degradation of GABARAPL1. ⺠GABARAPL1 is a new HSP90 client protein.
Keywords
RIP1UTRNonidet-P4017-N-allylamino-17-demethoxygeldanamycinGATE-16MAP-LC3Nbr1gec1GABAA receptor-associated proteinNP-4017-AAGGFPIPTGMCF-7GSTHSP90NSFHEK293isopropyl-β-d-thiogalactopyranosideMichigan cancer foundation-7microtubule-associated protein light chain 3N-ethylmaleimide sensitive factoruntranslated regionProteasome inhibitorsKORHeat shock protein 90Heat shock protein 90 (Hsp90)green fluorescent proteinreceptor interacting protein 1human embryonic kidney 293GABAAGABAARGABARAPkappa opioid receptor
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Authors
Stéphanie Seguin-Py, Géraldine Lucchi, Sophie Croizier, Fatima Z. Chakrama, Gilles Despouy, Jaclyn N. Le Grand, Patrick Ducoroy, Wilfrid Boireau, Michaël Boyer-Guittaut, Michèle Jouvenot, Annick Fraichard, Régis Delage-Mourroux,